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Comprar Uretol SR (Brand name: Detrol)

  • €0.85
  • Brand name: Detrol
  • Disponibilidad: En stock
  • Ingrediente activo: Tolterodine
Uretol SR es utilizado para el tratamiento de la vejiga hiperactiva con síntomas de frecuencia urinaria, urgencia y incontinencia.
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4 mg
Nombre del producto Por píldora Por paquete  
30 píldoras €3.17 €94.98
60 píldoras €2.45 €189.96 €147.21
90 píldoras €2.22 €284.93 €199.45
120 píldoras €2.10 €379.91 €251.69
180 píldoras €1.98 €569.87 €356.18
270 píldoras €1.90 €854.80 €512.88
2 mg
Nombre del producto Por píldora Por paquete  
30 píldoras €1.90 €56.95
60 píldoras €1.60 €113.90 €96.13
90 píldoras €1.50 €170.84 €135.31
120 píldoras €1.45 €227.79 €174.49
180 píldoras €1.40 €341.69 €252.85
270 píldoras €1.37 €512.53 €370.38
360 píldoras €1.36 €683.37 €487.93
1 mg
Nombre del producto Por píldora Por paquete  
30 píldoras €1.16 €34.71
60 píldoras €0.99 €69.43 €59.28
90 píldoras €0.93 €104.14 €83.84
120 píldoras €0.90 €138.86 €108.41
180 píldoras €0.88 €208.29 €157.54
270 píldoras €0.86 €312.43 €231.23
360 píldoras €0.85 €416.58 €304.92

INDICATIONS

Uretol SR is indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency.

INSTRUCTIONS

Take Uretol SR exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results.

Take Uretol SR with water. Do not crush, chew, break, or open a controlled-release capsule. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.

Store Uretol SR at room temperature away from moisture and heat.

If you missed a dose - take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

DOSAGE

The recommended dose of Uretol SR Capsules is 4 mg once daily with water and swallowed whole. The dose may be lowered to 2 mg daily based on individual response and tolerability; however, limited efficacy data are available for Uretol SR 2 mg.

For patients with mild to moderate hepatic impairment (Child-Pugh Class A or B) or severe renal impairment (CCr 10-30 mL/min), the recommended dose of Uretol SR is 2 mg once daily. Uretol SR is not recommended for use in patients with severe hepatic impairment (Child-Pugh Class C). Patients with CCKlO mL/min have not been studied and use of Uretol SR in this population is not recommended.

For patients who are taking drugs that are potent inhibitors of CYP3A4 [e.g., ketoconazole, clarithromycin, ritonavir], the recommended dose of Uretol SR is 2 mg once daily.

STORAGE

Store Uretol SR at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Uretol SR out of the reach of children and away from pets.

 

SAFETY INFORMATION

Before taking tolterodine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: problems emptying your bladder (urinary retention), severe blockage of stomach/intestines (gastric retention), a certain eye condition (uncontrolled narrow-angle glaucoma).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: other bladder problems (e.g., bladder outflow obstruction), stomach/intestinal disease (e.g., ulcerative colitis), slowed movement of stomach/intestines, severe constipation, controlled narrow-angle glaucoma, kidney disease, liver disease, enlarged prostate, a certain muscle disease (myasthenia gravis).

Tolterodine may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that require immediate medical attention. The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may affect the heart rhythm (see also Drug Interactions section). Before using tolterodine, tell your doctor or pharmacist if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/'water pills') or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using tolterodine safely.

This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages.

This medication can cause decreased sweating. Avoid becoming overheated in hot weather, saunas, or during exercise or other strenuous activities since heatstroke may occur.

Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be more sensitive to this drug.

This medication should be used only when clearly needed during pregnancy. It is not known whether Uretol SR will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

SIDE EFFECTS

Get emergency medical help if you have any of these signs of an allergic reaction to Uretol SR: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using Uretol SR and call your doctor at once if you have any of these serious side effects:

  • chest pain, fast or uneven heart rate;
  • confusion, hallucinations;
  • urinating less than usual or not at all; or
  • painful or difficult urination.

Less serious Uretol SR side effects may include:

  • dry mouth, dry eyes;
  • blurred vision;
  • dizziness, drowsiness;
  • constipation or diarrhea;
  • stomach pain or upset;
  • joint pain; or
  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

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Debemos tener en cuenta las contraindicaciones, advertencias y precauciones para no experimentar reacciones no deseadas y efectos secundarios. No obstante, algunos pacientes hipersensibles pueden experimentar reacciones adversas de diverso grado que enumeraremos en seguida. Acuda al médico sin dudarlo mucho, en el momento en que han observado los siguientes efectos secundarios y pónganse en contacto con un médico o un especialista médico en línea para eliminar el riesgo de algunas que otras graves consecuencias:

More Common

  • Abnormal vision, including difficulty with adjusting to distances
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • Abdominal or stomach pain
  • constipation
  • drowsiness
  • dry eyes
  • dry mouth
  • upset stomach

Less Common

  • Chest pain
  • chills
  • cough
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nausea
  • pain or tenderness around the eyes and cheekbones
  • shivering
  • shortness of breath or troubled breathing
  • sore throat
  • stuffy or runny nose
  • sweating
  • tightness of the chest or wheezing
  • trouble with sleeping
  • vomiting
  • Acid or sour stomach
  • belching
  • blurred vision
  • difficulty with moving
  • dizziness or lightheadedness
  • dry skin
  • fear or nervousness
  • feeling of constant movement of self or surroundings
  • heartburn
  • indigestion
  • sensation of spinning
  • sleepiness or unusual drowsiness
  • stomach discomfort
  • weight gain

Incidence Not Known

  • Being forgetful
  • bloating or swelling of the face, arms, hands, ankles, lower legs, or feet
  • confusion about identity, place, and time
  • difficulty with swallowing
  • dizziness
  • fast, pounding, or irregular heartbeat or pulse
  • hives
  • itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • mood or mental changes
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid weight gain
  • seeing, hearing, or feeling things that are not there
  • skin rash
  • tingling of the hands or feet
  • unusual tiredness or weakness
  • unusual weight gain or loss
Type Small Molecule
Accession Number DB01036  (APRD00146)
Groups Approved, Investigational
Synonyms
  • (+)-(R)-2-(alpha-(2-(Diisopropylamino)ethyl)benzyl)-p-cresol
  • (+)-Tolterodine
  • Tolterodina
  • Tolterodine
  • Tolterodinum
UNII WHE7A56U7K
CAS number 124937-51-5
Weight Average: 325.4876
Monoisotopic: 325.240564619
Chemical Formula C22H31NO
InChI
InChI=1S/C22H31NO/c1-16(2)23(17(3)4)14-13-20(19-9-7-6-8-10-19)21-15-18(5)11-12-22(21)24/h6-12,15-17,20,24H,13-14H2,1-5H3/t20-/m1/s1
IUPAC Name
2-[(1R)-3-[bis(propan-2-yl)amino]-1-phenylpropyl]-4-methylphenol
Protein binding

Approximately 96.3%.

Toxicity Not Available
Half life

1.9-3.7 hours

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